Some places have shown increases, including Canada, which has had a fraction of the cases and deaths of its southern neighbor, the United States.

The pandemic’s death toll has reached 4,580,381 deaths and 221,474,019 cases so far Sunday, according to Worldometers.info.

The United States remains the world leader in deaths at 666,219 with a 6% drop in one week and cases at 40,805,259 with a 6% decline from seven days ago. Its 8,504 deaths and 1,041,602 cases in the past week were the most in the world, according to Worldometers.info. On Saturday, the United States reported 527 deaths and 56,170 cases though most states don’t report data on weekends.

Conversely, Canada’s deaths increased 9% and cases rose 19%. But the numbers are a fraction of the United States and Mexico with 118 fatalities and 24,953 infections over seven days.

Canada ranks 26th worldwide in deaths with 27,021 including five Sunday, and 28th in cases with 1,516,167, including 1,978 most recently. Canada’s deaths record is 257 on Dec. 29 and the cases mark is 11,383 on Jan. 3, and a total of 1,468,813.

Mexico is fourth in the world in deaths with 262,868 as there was nearly no change in one week with 5,071, including 647 Saturday. The nation’s cases declined 18% with 93,977, including 15,586 most recently for 15th at 3,420,880.

Deaths are way down in Mexico from a one-day record of 1,803. The cases record of 28,953 was set Aug. 19.

North America’s death toll was 1,008,973 with a decline of 4% and cases were down 15% to 48,988,440.

Overall in North America, the United States has the highest rates per million — 1,998 deaths and 122,314 cases. Canada is at 709 for deaths and 38,684 for cases is 2,014 for deaths and 262,868 for cases.

Worldwide, the numbers are 587.4 deaths per million and 28,391 cases per million.

Brazil, which is second in the world with 583,628 deaths has a 2,722 per million and is third in the world in cases at 20,890,779 with 97,408 cases per million. Outside the Western Hemisphere, India with the second largest population in the world at 1.4 billion, is runner-up in cases with 32,988,673, including 23,639 per million and third in deaths at 440,533 at 316 per million.

Canada has the best vaccination rate of the three largest countries in North America with Canada’s one-shot vaccination rate has risen to 74.5% for the total population, according to Bloomberg tracking. In the United States, it is 62.3% and Mexico’s vaccination rate is 45.7%, though it was the first Latin American nation to begin vaccinating people.

Worldwide, vaccination doses grew by 260 million in one week to 5.46 billion with the world’s population of 7.9 billion.

Europe has administered 100 doses per 100 people, followed by North America at 95, South America at 85, Asia at 78, Oceania at 58 and Africa at 7.8, according to tracking by The New York Times. Most vaccines require two shots with boosters also occurring.

Despite strong vaccination numbers, modeling by the Public Health Agency of Canada shows boosting rates among young people and continuing masking and social distancing, the nation would avoid record cases in the fall.

If the current rate of COVID-19 transmission holds, the country could be reporting as many as 15,000 new daily cases by the middle of this month. But decreasing spread by 25% could cause the case numbers to plateau, and then decrease later in September.

More than 84% of eligible people had received at least one dose 77% percent were fully vaccinated, according to data through the end of last month.

“We have a window of opportunity to rapidly accelerate vaccine uptake and close the protection gap in younger age groups with the lowest vaccine coverage,” Chief Public Health Officer Theresa Tam said at a news conference Friday.

Ontario, British Columbia and Quebec are in the process of implementing vaccine passports.

In North America, the United States’ non-essential travel ban with Canada and Mexico has been extended to Sept. 21. It began one year ago in March. Earlier, Canada announced it was reopening to vaccinated Americans.

Mexico has never closed its air borders or required incoming travelers to go into mandatory quarantine.

But state tourism ministers want the federal government to implement new coronavirus-related health and safety protocols. They want travelers to present a COVID-19 vaccination certificate or a negative test result.

Hotspots include tourist destinations such as Cancun and Los Cabos.