Top scientists from leading academic centers are banding together to answer a key question about the root cause of long COVID – whether fragments of the coronavirus persist in the tissues of some individuals.

The effort, known as the Long Covid Research Initiative, aims to streamline research and quickly pivot to clinical trials of potential treatments. By sharing diverse skill sets and resources, the group hopes to uncover the scientific underpinnings of the disease and use that to design evidence-based trials.

Long COVID is a complex, poorly understood, disabling condition that can last for many months after an initial COVID infection, leaving many of its sufferers unable to work. It affects nearly one in five American adults who have had COVID, according to the U.S. Centers for Disease Control and Prevention.

The initiative is backed by an initial $15 million from Balvi, a scientific investment fund formed by Vitalik Buterin, co-founder of the blockchain platform Ethereum.

It includes scientists from Harvard University, Stanford University, the University of California, San Francisco, Yale University and the J. Craig Venter Institute.

“The first thing you need to understand in long COVID is if patients still have the virus in them or not,” said Dr. Amy Proal of the nonprofit PolyBio Research Foundation, an expert in infection-associated chronic disease who will serve as chief scientific officer of the initiative.

Currently, there are no proven treatments for long COVID, which affects more than 150 million people globally.

A growing body of evidence points to the presence of virus in tissues that continue to provoke a response from the immune system, she said.

That may help explain the cascade of some 200 symptoms associated with long COVID, including pain, fever, headaches, cognitive impairment, shortness of breath and exhaustion after minimal amounts of activity.

Researchers will use advanced imaging and gene-sequencing techniques looking for evidence of the virus in tissues and analyzing its affects on the immune system.

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