COVID Vaccine in Pregnancy Not Tied to Adverse Outcomes

Pregnant women who received a COVID-19 vaccine faced no additional risks of adverse birth outcomes compared to those who were not vaccinated, according to a retrospective cohort study.

COVID-19 vaccination in pregnancy was not associated with an increased risk of preterm birth (adjusted hazard ratio [aHR] 0.91, 95% CI 0.82-1.01) or of small-for-gestational-age (SGA) at birth (aHR 0.95, 95% CI 0.87-1.03), reported Heather Lipkind, MD, MS, of Yale University in New Haven, Connecticut, and colleagues in Mortality and Morbidity Weekly Report.

However, only 21.8% of the more than 40,000 pregnant women in the study were vaccinated, the researchers noted.

Lipkind and colleagues added that while the absolute risk of severe morbidity associated with COVID-19 in pregnancy is low, pregnant women with symptomatic illness have an increased risk of ICU admission, invasive ventilation, life support, and even death versus non-pregnant women with COVID-19. Additionally, researchers are gathering more evidence about the benefits of COVID-19 vaccination in pregnancy, such as the presence of antibodies in cord blood.

“Together, these findings reinforce the importance of communicating the risks for COVID-19 during pregnancy, the benefits of vaccination, and information on the safety and effectiveness of COVID-19 vaccination during pregnancy,” Lipkind’s group stated.

The CDC recommends COVID-19 vaccination during pregnancy, and additionally suggests that all adults — including those who are pregnant, breastfeeding, or trying to get pregnant — get a booster shot.

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